Kniha Structural Alignment Layal Kazma

Structural Alignment

A Graph-Theoretic Approach

Autor: Layal Kazma
Jazyk: Angličtina
Väzba: Brožovaná
Vydavateľ: VDM Verlag
Dostupnosť: U vydavateľa na objednávku
Odosielame za 17-27 dní
48.41
Structural alignment is the process of finding similarities between a pair of proteins based on thei...

Informácie o knihe

Autor
Jazyk
Angličtina
Väzba
Kniha - Brožovaná
Vydalo
2011
Stránok
80
EAN
9783639279368
ISBN
3639279360
Enbook ID
06835132
Vydavateľ
Hmotnosť
127
Rozmery
152 x 229 x 5

Kompletný popis

Structural alignment is the process of finding similarities between a pair of proteins based on their three-dimensional shape. Accurate detection of such similarities could reveal evolutionary relationships and predict the functions of different proteins. Despite the existing algorithms, the protein structure alignment problem is not completely solved. In this work a graph-theoretic approach is considered, which consists of representing tertiary protein structures as labeled graphs, and interpreting the structural alignment problem as a particular case of the Maximum Common Subgraph (MCS) problem. Our algorithm was then implemented under parallel platforms using a combination of threads and message passing techniques. Experiments were performed on a set of proteins selected randomly from the Protein Data Bank. The experiments proved the time- efficiency and accuracy of our method when compared to several other algorithms.

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