Kniha Streptozotocin Elizabeth L Gauthier

Streptozotocin

Uses, Mechanism of Action & Side Effects

Jazyk: Angličtina
Väzba: Pevná
Dostupnosť: 50 % šanca
Prehľadáme celý svet
199.12
Streptozotocin (STZ), an antibiotic and anticancer agent, is the most prominent diabetogenic chemica...

Informácie o knihe

Jazyk
Angličtina
Väzba
Kniha - Pevná
Vydalo
2014
Stránok
170
EAN
9781631172557
ISBN
9781631172557
Enbook ID
06439963
Hmotnosť
470
Rozmery
181 x 263 x 14

Kompletný popis

Streptozotocin (STZ), an antibiotic and anticancer agent, is the most prominent diabetogenic chemical agent in diabetes research due to its cytotoxicity in pancreatic beta-cells. The selective toxicity of STZ to beta cells occurs because of its preferential accumulation in beta cells through uptake via GLUT2 glucose transporter. Insulin dependent diabetes mellitus can be induced by either single high dose or multiple low-dose STZ injections. At low dose, STZ induces pancreatic beta-cell apoptosis and at high dose it causes necrosis. Though STZ itself can cause carcinogenesis and renal, hepatic and muscle myoblast toxicity, these side effects can be minimised or completely avoided by using lower doses. This book discusses in further detail the different ways in which streptozotocin is used in the medical field.

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