Pattern Discovery for Deciphering Gene Regulation

Name: Pattern Discovery for Deciphering Gene Regulation
Brand: VDM Verlag
SKU: 9783639362794
Price: 58.24 EUR
Availability: InStock

with Evolutionary Computation and Data Mining Based Methods

Autor: Tak-Ming Chan

Jazyk:

Väzba: Brožovaná

Vydavateľ: VDM Verlag

Dostupnosť: U vydavateľa na objednávku

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58.24 €

Transcription Factor (TF) and Transcription Factor Binding Site (TFBS) bindings are fundamental prot...

Informácie o knihe

Autor

Tak-Ming Chan

Jazyk

Angličtina

Väzba

Kniha - Brožovaná

Vydalo

2011

Stránok

144

EAN

9783639362794

ISBN

3639362799

Enbook ID

06843150

Vydavateľ

VDM Verlag

Hmotnosť

222

Rozmery

152 x 229 x 9

Kompletný popis

Transcription Factor (TF) and Transcription Factor Binding Site (TFBS) bindings are fundamental protein-DNA interactions in transcriptional regulation. TFs and TFBSs are conserved to form patterns (motifs) due to their important roles for controlling gene expressions and finally affecting functions and appearances. Pattern discovery is thus important for deciphering gene regulation, which has tremendous impacts on the understanding of life, bio-engineering and therapeutic applications. This thesis contributes to pattern discovery involving TFBS motifs and TF-TFBS associated sequence patterns based on Evolutionary Computation (EC), especially Genetic Algorithms (GAs), which are promising for bioinformatics problems with huge and noisy search space. On TFBS motif discovery, three novel GA based algorithms are developed, namely GALF-P with focus on optimization, GALF-G for modeling, and GASMEN for spaced motifs. TF-TFBS associated sequence pattern (rule) discovery is further investigated for better deciphering protein-DNA interactions in regulation. We for the first time generalize previous exact TF-TFBS rules to approximate ones using a progressive approach.

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Pattern Discovery for Deciphering Gene Regulation

with Evolutionary Computation and Data Mining Based Methods

Informácie o knihe

Kompletný popis

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Zákazníci, ktorí si kúpili túto knihu, kúpili tiež