Kniha Modelling Proteasome Dynamics in a Bayesian Framework Sabine Stübler

Modelling Proteasome Dynamics in a Bayesian Framework

Jazyk: Angličtina
Väzba: Brožovaná
Dostupnosť: Skladom u dodávateľa v malom množstve
Odosielame za 13-18 dní
54.21
Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and a...

Informácie o knihe

Jazyk
Angličtina
Väzba
Kniha - Brožovaná
Vydalo
2017
Stránok
96
EAN
9783658201661
ISBN
3658201665
Enbook ID
18368854
Hmotnosť
1557
Rozmery
148 x 210 x 6

Kompletný popis

Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor's transport parameters for strong or isoform-specific inhibition.

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