Mitochondrial Alterations in Solid Carcinomas

Name: Mitochondrial Alterations in Solid Carcinomas
Brand: VDM Verlag Dr. Mueller E.K.
SKU: 9783836486408
Price: 48.41 EUR
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Relationship between Tumorgenesis of Human Kidney Carcinomas and Mitochondrial DNA (mtDNA) Alterations

Autor: David Meierhofer

Jazyk:

Väzba: Brožovaná

Vydavateľ: VDM Verlag Dr. Mueller E.K.

Dostupnosť: U vydavateľa na objednávku

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Alterations of the respiratory chain and mutations of the mitochondrial DNA (mtDNA) have been extens...

Informácie o knihe

Autor

David Meierhofer

Jazyk

Angličtina

Väzba

Kniha - Brožovaná

Vydalo

2008

Stránok

112

EAN

9783836486408

ISBN

3836486407

Enbook ID

07008180

Vydavateľ

VDM Verlag Dr. Mueller E.K.

Hmotnosť

159

Rozmery

152 x 229 x 6

Kompletný popis

Alterations of the respiratory chain and mutations of the mitochondrial DNA (mtDNA) have been extensively investigated in a wide variety of neoplasias. However, no obvious correlation of a certain type of tumor and mtDNA mutations has been reported so far. I compared both, enzymatic measurements of the respiratory chain and mtDNA mutations in renal carcinomas and renal oncocytomas. To enable a high throughput screen of mtDNA variations, I developed a DHPLC-based protocol for a rapid detection of unknown variations of the entire human mtDNA. The benign renal oncocytomas were in clear contrast to the malign renal carcinomas. The oncocytomas showed significantly increased Krebs cycle- and OXPHOS enzyme activities, except a total breakdown of the complex I enzyme activity. The mutation screening revealed frame shift mutations, encoding mitochondrial ND genes in 8 out of 12 oncocytomas. All these somatic frame shift mutations displayed a homoplasmy of 100%. This study shows for the first time a direct correlation of mtDNA mutations in a specific type of cancer, which leads to a total lack of complex I enzyme activity in the respiratory chain.

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Mitochondrial Alterations in Solid Carcinomas

Relationship between Tumorgenesis of Human Kidney Carcinomas and Mitochondrial DNA (mtDNA) Alterations

Informácie o knihe

Kompletný popis

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