Microarray Gene Expression Data Integration and Cancer Signatures

Name: Microarray Gene Expression Data Integration and Cancer Signatures
Brand: VDM Verlag Dr. Mueller E.K.
SKU: 9783639085532
Price: 47.48 EUR
Availability: InStock

Autor: Lei Xu

Jazyk:

Väzba: Brožovaná

Vydavateľ: VDM Verlag Dr. Mueller E.K.

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47.48 €

Over the past decade, microarray gene expression datahas been widely used to identify cancer genesig...

Informácie o knihe

Autor

Lei Xu

Jazyk

Angličtina

Väzba

Kniha - Brožovaná

Vydalo

2008

Stránok

120

EAN

9783639085532

ISBN

3639085531

Enbook ID

06817728

Vydavateľ

VDM Verlag Dr. Mueller E.K.

Hmotnosť

172

Rozmery

152 x 229 x 6

Kompletný popis

Over the past decade, microarray gene expression datahas been widely used to identify cancer genesignatures that could complement conventionalhistopathologic evaluation to increase the accuracyof cancer diagnosis and prognosis. However, due tothe limited sample size of individual studies, thereis often only a small overlap between signatures forspecific cancers obtained in different studies. Withthe rapid accumulation of microarray data, it is ofgreat interest to understand how to combinemicroarray data across studies of similar cancers inorder to increase sample size, which could lead tothe identification of more reliable gene signaturesof specific cancers. This book provides a novelstatistical method, based on the top-scoring pairsclassifier family, for inter-study microarray dataintegration. By incorporating this new method intodifferent statistical models, we can identify robustgene signatures for cancer diagnosis and prognosisfrom integrated microarray data. This book isprimarily aimed at cancer researchers, especially inthe emerging field of cancer bioinformatics, butshould also be valuable to statisticians and medicalresearchers entering the field.

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