Graph-based approaches to protein structure comparison

Name: Graph-based approaches to protein structure comparison
Brand: Sudwestdeutscher Verlag Fur Hochschulschriften AG
SKU: 9783838134529
Price: 77.38 EUR
Availability: InStock

Autor: Marco Mernberger

Jazyk:

Väzba: Brožovaná

Vydavateľ: Sudwestdeutscher Verlag Fur Hochschulschriften AG

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The comparison of protein structures is a central task in structural bioinformatics. Drawing upon st...

Informácie o knihe

Autor

Marco Mernberger

Jazyk

Nemčina

Väzba

Kniha - Brožovaná

Vydalo

2012

Stránok

248

EAN

9783838134529

ISBN

3838134524

Enbook ID

07008919

Vydavateľ

Sudwestdeutscher Verlag Fur Hochschulschriften AG

Hmotnosť

367

Rozmery

152 x 229 x 14

Kompletný popis

The comparison of protein structures is a central task in structural bioinformatics. Drawing upon structural information enables the inference of function for unknown proteins, even without apparent homology on the sequence level. Regarding enzyme function, the conformation of the catalytic site or the binding pocket accomodating bound substrates or ligands is especially interesting due to structural constraints imposed by the catalyzed reaction or the bound molecule. Hence, these sites are likely to be similar in proteins interacting with similar molecules. This is especially appealing in pharmaceutics as it allows for the prediction of cross reactivities prior to expensive clinical trials. In this book, Marco Mernberger gives an introduction to protein structure comparison with a special regard to protein binding pockets and developes different graph-based approaches based on global, local and semi-global strategies. As it is not apparent which principle is more suitable for the detection of cross reactivities, a comparative study is conducted, highlighting the advantages and drawbacks of local, global and semi-global methods.

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Graph-based approaches to protein structure comparison

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