Computational Methods for Fragment Spectrum Interpretation

Name: Computational Methods for Fragment Spectrum Interpretation
Brand: VDM Verlag
SKU: 9783639228588
Price: 47.39 EUR
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Computational Interpretation of Tandem MS Spectra Including Fragment Ions with Post-Translational Modifications

Autor: Jonathan Rameseder, Lennart Martens

Jazyk:

Väzba: Brožovaná

Vydavateľ: VDM Verlag

Dostupnosť: Skladom u dodávateľa

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Post-translational modifications (PTMs) are of critical importance for a vast range of cellular proc...

Informácie o knihe

Autor

Jonathan Rameseder, Lennart Martens

Jazyk

Angličtina

Väzba

Kniha - Brožovaná

Vydalo

2010

Stránok

EAN

9783639228588

ISBN

3639228588

Enbook ID

06830633

Vydavateľ

VDM Verlag

Hmotnosť

Rozmery

152 x 229 x 10

Kompletný popis

Post-translational modifications (PTMs) are of critical importance for a vast range of cellular processes such as growth control and signal transduction. Mass spectrometry (MS) can shed light on the characteristics of PTMs to gain insight into the mechanisms of numerous diseases including cancer. However, interpretation of tandem MS spectra including fragment ions with PTMs from high-throughput experiments is a complex challenge. The high number and diversity of known PTMs as well as suboptimal quality of spectra compromise the identification of PTMs in MS experiments. In this book, an efficient algorithm for the computational interpretation of tandem MS spectra including fragment ions with PTMs is described. Information on both precursor and fragment ion level is utilized and an arbitrary number of PTMs is considered. A robust statistical noise intensity model is developed to compensate for low spectrum quality. Finally, the algorithm is successfully applied on the fragment spectra in the PRIDE proteomics data repository to render it suitable for statistical machine learning investigations.

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Computational Methods for Fragment Spectrum Interpretation

Computational Interpretation of Tandem MS Spectra Including Fragment Ions with Post-Translational Modifications

Informácie o knihe

Kompletný popis

Mohlo by vás zaujímať

Zákazníci, ktorí si kúpili túto knihu, kúpili tiež