Chemical Mutagens

Name: Chemical Mutagens
Brand: Springer-Verlag New York Inc.
SKU: 9781461336969
Price: 50.04 EUR
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Principles and Methods for Their Detection Volume 8

Autor: Frederick J. De Serr, A. Hollaender

Jazyk:

Väzba: Brožovaná

Vydavateľ: Springer-Verlag New York Inc.

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Volume 8 of Chemical Mutagens covers a wide range of topics in this continuously changing field. Thi...

Informácie o knihe

Autor

Frederick J. De Serr, A. Hollaender

Jazyk

Angličtina

Väzba

Kniha - Brožovaná

Vydalo

2011

Stránok

386

EAN

9781461336969

ISBN

1461336961

Enbook ID

02180304

Vydavateľ

Springer-Verlag New York Inc.

Hmotnosť

589

Rozmery

152 x 229 x 22

Kompletný popis

Volume 8 of Chemical Mutagens covers a wide range of topics in this continuously changing field. This volume includes chapters on the detection of genetic damage in mammalian sperm both at specific loci and over the entire genome. The discussion of in vitro techniques for working with mammalian cells covers not only specific locus assays but also cellular activation systems. Another chapter extensively discusses the need for a revised protocol for the micronucleus assay. Structure activity relationships are investigated in a chapter dealing with hair dye constituents. One of the most comprehensive chapters deals with problems associated with the detection of mutagenic effects in defined human populations. Finally, there is a detailed presentation of a comprehensive study tabulating the genetic bioassay data on some known or suspected human carcinogens. In keeping with our policy of publishing important legislation in the area of chemical mutagens, we have also included the Council of the European Communities Directive of 18 September 1979. Frederick J. de Serres Research Triangle Park, North Carolina vii Contents Chapter 1 Detection of Effects of Mutagens in Human Populations George R. Hoffmann 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. Monitoring Progeny for Evidence of Germ-Cell Mutations. . . . . 3 2. 1. The Classical Approach: Phenotypic Monitoring . . . . . . . 3 2. 2. Monitoring for Changes in Gene Products . . . . . . . . . . . 7 3. Detection of Gene Mutations in Somatic Cells. . . . . . . . . . . . . 9 3. 1. Drug-Resistant Lymphocytes . . . . . . . . . . . . . . . . . . . . . . 9 3. 2. Hemoglobin Variants . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 4. Nongenetic Indicators of Mutagen Exposure . . . . . . . . . . . . . 21 4. 1. Alkylation of Proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 4. 2. DNA Damage . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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Chemical Mutagens

Principles and Methods for Their Detection Volume 8

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