Cell adhesion behavior on molecularly engineered surfaces

Name: Cell adhesion behavior on molecularly engineered surfaces
Brand: LAP Lambert Academic Publishing
SKU: 9783659190391
Price: 77.51 EUR
Availability: InStock

Mechanisms of Cell/Surface Interaction

Autor: Ning Cai

Jazyk:

Väzba: Brožovaná

Vydavateľ: LAP Lambert Academic Publishing

Dostupnosť: U vydavateľa na objednávku

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Effective attachment of cells on biomaterials is one important requirement in designing engineered t...

Informácie o knihe

Autor

Ning Cai

Jazyk

Angličtina

Väzba

Kniha - Brožovaná

Vydalo

2012

Stránok

220

EAN

9783659190391

Enbook ID

06901451

Vydavateľ

LAP Lambert Academic Publishing

Hmotnosť

308

Rozmery

150 x 220 x 11

Kompletný popis

Effective attachment of cells on biomaterials is one important requirement in designing engineered tissue substitute. Better understanding of biophysical responses of adherent cells is of great importance in optimizing biomaterial surface for tissue engineering applications. In this work, poly(lactic acid) (PLA) and carbon nanotubes (CNT), were surface-modified with extracellular matrix (ECM) proteins to improve their compatibility. The results of adhesion dynamics of porcine esophageal fibroblasts (PEFs) on ECM protein-immobilized PLA and CNT monolayer demonstrate the different biophysical responses of PEFs on unmodified and ECM protein-modified biomaterial surfaces. ECM protein immobilization effectively promotes adhesion of PEFs to biomaterials surfaces. In addition, it is found that functional blocking of 1 integrin impaires cell-fibronectin interactions. Adhesion strength is tightly correlated to focal adhesion density, which is explained by peeling and fracture models. Furthermore, Weibull distribution is proved to satisfactorily describe cell adhesion strength in adherent cell population.

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Cell adhesion behavior on molecularly engineered surfaces

Mechanisms of Cell/Surface Interaction

Informácie o knihe

Kompletný popis

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Zákazníci, ktorí si kúpili túto knihu, kúpili tiež