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CD4 Molecule

Name: CD4 Molecule
Brand: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
SKU: 9783642798009
Price: 99.78 EUR
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Roles in T Lymphocytes and in HIV Disease

Autor: Dan R. Littman

Jazyk:

Väzba: Brožovaná

Vydavateľ: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG

Dostupnosť: Skladom u dodávateľa

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During the late 1970's the application of hybridoma technology led to an explosion in the discovery...

Informácie o knihe

Autor

Dan R. Littman

Jazyk

Angličtina

Väzba

Kniha - Brožovaná

Vydalo

2011

Stránok

182

EAN

9783642798009

ISBN

9783642798009

Enbook ID

06620614

Vydavateľ

Springer-Verlag Berlin and Heidelberg GmbH & Co. KG

Hmotnosť

312

Rozmery

155 x 235 x 12

Kompletný popis

During the late 1970's the application of hybridoma technology led to an explosion in the discovery and characterization of proteins expressed at the surface of hematopoietic cells. The understanding of T lymphocyte biology benefited enormously from this advance and from newly developed techniques for obtaining clonal T cells. Application of these methodologies resulted in the identification of the clonally restricted T cell antigen receptors (TCRs) and of a number of other molecules expressed more broadly on T cells. Among these, the CD4 and CD8 glycoproteins stood out because they were differentially expressed on distinct functional subsets of T lymphocytes. Moreover, blocking studies with monoclonal antibodies sug gested a functional role for CD4 and CD8 in T cell responses to antigen. Shortly thereafter, it was shown that T helper cells were the primary targets for the human immunodeficiency virus (HIV) and that CD4 serves as the viral receptor on these cells. These findings fueled an intense interest in CD4 during the last decade, in the hope that understanding the molecular nature of the HIV-CD4 interaction could hold the key to controlling AIDS.