Bootstrap methods for multi-factorial dose-response designs

Name: Bootstrap methods for multi-factorial dose-response designs
Brand: Südwestdeutscher Verlag für Hochschulschriften
SKU: 9783838109305
Price: 46.66 EUR
Availability: InStock

Methodology and applications

Autor: Peter Frommolt

Jazyk:

Väzba: Brožovaná

Vydavateľ: Südwestdeutscher Verlag für Hochschulschriften

Dostupnosť: Skladom u dodávateľa

Odosielame za 5-8 dní

46.66 €

Bifactorial designs are used to test for the efficacy§ of fixed combinations of two (or more) drugs....

Informácie o knihe

Autor

Peter Frommolt

Jazyk

Angličtina

Väzba

Kniha - Brožovaná

Vydalo

2009

Stránok

104

EAN

9783838109305

Enbook ID

06938532

Vydavateľ

Südwestdeutscher Verlag für Hochschulschriften

Hmotnosť

173

Rozmery

150 x 220 x 7

Kompletný popis

Bifactorial designs are used to test for the efficacy§ of fixed combinations of two (or more) drugs. Researchers are§ interested in the question if a combination has a§ significantly higher efficacy than either component drug§ alone. The power of the existing methods strongly depends on§ a nuisance parameter representing how much the respective§ means differ between the groups treated by the component§ drugs. Furthermore, the methods are only applicable under§ rather strict assumptions on the data. In this work, the§ distributions of the respective test statistics are§ approximated by bootstrap methods with data-based estimation§ of the marginal differences to overcome these limitations.§ This gives interesting insights about the role of unknown§ nuisance parameters in resampling procedures. The methods§ described are also expanded to related problems and more§ general questions and their power is evaluated by simulation§ studies. Finally, some examples for typical applications are§ worked out.

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Bootstrap methods for multi-factorial dose-response designs

Methodology and applications

Informácie o knihe

Kompletný popis

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