Nanoparticulate Drug Delivery Systems: Strategies, Technologies, and Applications

Frank discussions of opportunities and challenges pointthe way to new, more effective drug delivery systems

Interest in nanomedicine has grown tremendously, fueled by theexpectation that continued research will lead to the safe, efficient, and cost-effective delivery of drugs or imaging agentsto human tissues and organs. The field, however, has faced severalchallenges attempting to translate novel ideas into clinicalbenefits. With contributions from an international team of leadingnanomedicine researchers, this book provides a practical assessmentof the possibilities and the challenges of modern nanomedicine thatwill enable the development of clinically effective nanoparticulatedrug delivery products and systems.

Nanoparticulate Drug Delivery Systems focuses on therationales and preclinical evaluation of new nanoparticulate drugcarriers that have yet to be thoroughly reviewed in the literature.The first chapter sets the stage with a general overview oftargeted nanomedicine. The book then explores new and promisingnanoparticulate drug delivery systems, including:

• Lipid nanoparticles for the delivery of nucleic acids
• Multifunctional dendritic nanocarriers
• Polymer drug nanoconjugates

Next, the book presents new opportunities and challenges fornanoparticulate drug delivery systems, including:

• Clearance of nanoparticles during circulation
• Drug delivery strategies for combatting multiple drugresistance
• Toxicological assessment of nanomedicine

Chapters offer state-of-the-technology reviews with extensivereferences to facilitate further investigation. Moreover, eachchapter concludes with an expert assessment of remainingchallenges, pointing the way to solutions and new avenues ofresearch.

With its frank discussions of opportunities and challenges, Nanoparticulate Drug Delivery Systems sets a solidfoundation for new research leading to the discovery anddevelopment of better nanomedicines.